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Herb Profile
Gastrodia
Gastrodia elata
Gastrodia (Gastrodia elata) carries a Grade C rating — limited evidence.
Last reviewed: •3 sources citedReport a correctionProfile-wide ·C Limited
Use extra caution — CNS active potential; avoid stacking with sedatives, alcohol, sleep aids, antidepressants, or other psychoactive supplements without clinician review. Details
- Evidence
- Limited Evidence
- Typical onset
- Varies by prep
- Safety rating
- High caution
- Best for
- Neuroprotective, Cognitive Support, Anticonvulsant, Stress
- Avoid / review if
- Pregnancy/Breastfeeding Without Guidance, Sedative Use Without Review, May Add To CNS Depressant Or Antihypertensive Effects
At a glance
From this profile's structured data- Evidence
- Grade C
- Safety
- CNS-active potential; avoid stacking with sedatives, alcohol, sleep aids, antidepressants, or other psychoactive supplements without clinician review.
- Profile context
- neuroprotective, cognitive_support, anticonvulsant
Next stepsWhere to go next — guides & comparisons
Continue reading
- If you want help sleeping → Sleep guides
- If you want help with anxiety or stress → Anxiety & stress guides
- If you want sharper focus → Focus guides
- If you want to browse more herbs → All herbs
Safety
Safety & Cautions
CNS active potential; avoid stacking with sedatives, alcohol, sleep aids, antidepressants, or other psychoactive supplements without clinician review. Avoid pregnancy/breastfeeding use unless supervised.
High caution
Caution level: High. Multiple caution categories apply, or the record uses avoid/contraindication language.
- Interaction-AwareMedication or interaction context is explicitly noted.
- Pregnancy/Breastfeeding CautionPregnancy or breastfeeding caution language is present.
Detailed safety fields
Pregnancy, breastfeeding, and contraindications
- Pregnancy/Breastfeeding Without Guidance
- Sedative Use Without Review
- May Add To CNS Depressant Or Antihypertensive Effects
- Limited Interaction Data.
Safety classifications
- Interaction-Aware: Medication or interaction context is explicitly noted.
- Pregnancy/Breastfeeding Caution: Pregnancy or breastfeeding caution language is present.
Full safety note
- CNS active potential; avoid stacking with sedatives, alcohol, sleep aids, antidepressants, or other psychoactive supplements without clinician review. Avoid pregnancy/breastfeeding use unless supervised.
Safety labels
- Interaction-Aware
- Pregnancy/Breastfeeding Caution
Evidence-based safety
Caution when combined
Severity and certainty are shown separately. A high-priority caution can still be theoretical: these pairings are screened from shared contraindication mechanisms and are not automatically documented clinical interactions. Provenance identifies the source fields that produced each flag; it does not upgrade the certainty of the pairwise claim.
Moderate Caution
149 flagged pairingsBlood-pressure effects · Sedation / CNS depression
Moderate Caution
149 flagged pairingsBlood-pressure effects · Sedation / CNS depression
Representative pairings are shown below. Large mechanism groups are intentionally summarized to keep profiles focused and crawl-efficient.
Blood-pressure effectsCertainty: Theoretical
Data provenance recorded for 81 of 81 pairings in this mechanism group.
- Agmatine sulfate — Theoretical interaction certainty
- ajoene — Theoretical interaction certainty
- Allicin — Theoretical interaction certainty
- American Ginseng Extract — Theoretical interaction certainty
- Andrographis — Theoretical interaction certainty
- Angelica Dahurica — Theoretical interaction certainty
- Astaxanthin — Theoretical interaction certainty
- Astragalus Membranaceus — Theoretical interaction certainty
- Beetroot extract — Theoretical interaction certainty
- Berberis — Theoretical interaction certainty
- Bicarbonate — Theoretical interaction certainty
- Black Seed — Theoretical interaction certainty
+69 more pairings share this mechanism. Use the Safety Checker to review a specific combination.
Sedation / CNS depressionCertainty: Theoretical
Data provenance recorded for 68 of 68 pairings in this mechanism group.
- American Yellow Lotus — Theoretical interaction certainty
- Artemisia Absinthium — Theoretical interaction certainty
- Ashwagandha (Withania somnifera) — Theoretical interaction certainty
- Bacopa — Theoretical interaction certainty
- Black Seed — Theoretical interaction certainty
- Black Tea — Theoretical interaction certainty
- Blue Lotus — Theoretical interaction certainty
- Calamus — Theoretical interaction certainty
- Catuba — Theoretical interaction certainty
- Celastrus Paniculatus — Theoretical interaction certainty
- Chamomile — Theoretical interaction certainty
- Chinese Skullcap — Theoretical interaction certainty
+56 more pairings share this mechanism. Use the Safety Checker to review a specific combination.
Evidence
Evidence Summary
Evidence lens
Read as directional context, not settled clinical proof.
LimitedLimited Evidence
Human clinical evidence: Not the primary signal
Mechanistic / preclinical: Mechanism mapped — Stress Response Modulation · Neuroprotective Activity
Research maturity: Theoretical / mechanistic research — Mechanistic or unresolved evidence is kept separate from established human outcomes.
Safety boundary: Safety note available — CNS active potential; avoid stacking with sedatives, alcohol, sleep aids, antidepressants, or other psychoactive supplements without clinician review.
This profile cites 3 human studies.
Study design details
Evidence Grade
Grade C: Limited Evidence
Evaluation of methodological rigor, population reach, and evidence alignment.
- Design Match
- Narrative review
- Risk of Bias
- High
- Consistency
- Not assessed
Strongest recorded design is a narrative review, drawn from 2 recorded studies, none of which measured an outcome in people.
How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
- Strong
- Multiple RCTs, consistent direction, adequate effect size
- Moderate
- Some RCTs or consistent observational data in humans
- Preliminary / Mixed
- Animal or in-vitro only, or conflicting human data
- Traditional / Theoretical
- Traditional use only; no controlled human trials
Clinical Study Summaries (3)0 human evidence sources · 0 human trials · Participant totals not consistently reported · Consistency not yet classifiable
Filter by study class
Showing 3 of 3 studies.
What the evidence actually shows
This table contains 3 structured sources, including 0 human evidence sources; 0 are human trials.
| Study | Design | N | Dose | Duration | Population | Outcome | Result & magnitude | Source |
|---|---|---|---|---|---|---|---|---|
Review on pharmacological effects of gastrodin Xiao G et al. · Arch Pharm Res · 2023 Background | Narrative review Summarizes selected literature without the full prespecified search and selection methods of a systematic review. | — | — | — | — | — | — | PubMed → |
Gastrodin: a comprehensive pharmacological review Wang Y et al. · Naunyn Schmiedebergs Arch Pharmacol · 2024 Background | Narrative review Summarizes selected literature without the full prespecified search and selection methods of a systematic review. | — | — | — | — | — | — | PubMed → |
Wang W et al. · Phytomedicine · 2024 Background | Other / unclear The study design is not yet classified clearly enough to infer its place in the evidence hierarchy. | — | — | — | — | — | — | PubMed → |
Dosing & Timing
- No standardized dose
- Preparation specific; use standardized product label for Tuber decoction and require source backed dosage review before therapeutic claims.
How Gastrodia works
Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.
Mechanism Pathway — How Gastrodia Works
CompoundTarget / ReceptorMechanismEffect / Outcome
Mechanisms & biological pathways (preclinical)
- Stress Response Modulation
- Neuroprotective Activity
Compare related active botanicals
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Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Editorial Review
Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.
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