Herb Profile

Soursop

Annona muricata

It must be framed carefully because anticancer folklore claims greatly exceed evidence and safety certainty.

Last reviewed: •3 sources citedReport a correctionProfile-wide ·C Limited

Use extra caution — Avoid high dose or chronic supplement use; annonaceous acetogenins have neurotoxicity concerns. Details

Evidence
Limited Evidence
Typical onset
Varies by prep
Safety rating
High caution
Best for
Antioxidant, Stress resilience
Soursop monograph visual
Generated profile category visual

At a glance

From this profile's structured data
Evidence
Grade C
Safety
Avoid high-dose or chronic supplement use; annonaceous acetogenins have neurotoxicity concerns.
Profile context
antioxidant
Next steps

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Safety

Safety & Cautions

Avoid high dose or chronic supplement use; annonaceous acetogenins have neurotoxicity concerns. Caution with Parkinsonism, neurologic disease, pregnancy, and sedating medications.

High caution

Caution level: High. Multiple caution categories apply, or the record uses avoid/contraindication language.

  • Interaction-AwareMedication or interaction context is explicitly noted.
  • Pregnancy/Breastfeeding CautionPregnancy or breastfeeding caution language is present.
Detailed safety fields

Safety classifications

  • Interaction-Aware: Medication or interaction context is explicitly noted.
  • Pregnancy/Breastfeeding Caution: Pregnancy or breastfeeding caution language is present.

Full safety note

  • Avoid high dose or chronic supplement use; annonaceous acetogenins have neurotoxicity concerns. Caution with Parkinsonism, neurologic disease, pregnancy, and sedating medications.

Safety labels

  • Interaction-Aware
  • Pregnancy/Breastfeeding Caution

Evidence-based safety

Caution when combined

Severity and certainty are shown separately. A high-priority caution can still be theoretical: these pairings are screened from shared contraindication mechanisms and are not automatically documented clinical interactions. Provenance identifies the source fields that produced each flag; it does not upgrade the certainty of the pairwise claim.

Moderate Caution

191 flagged pairings

Blood-sugar lowering · Blood-pressure effects

Representative pairings are shown below. Large mechanism groups are intentionally summarized to keep profiles focused and crawl-efficient.

Blood-sugar loweringCertainty: Theoretical

Data provenance recorded for 110 of 110 pairings in this mechanism group.

+98 more pairings share this mechanism. Use the Safety Checker to review a specific combination.

Blood-pressure effectsCertainty: Theoretical

Data provenance recorded for 81 of 81 pairings in this mechanism group.

+69 more pairings share this mechanism. Use the Safety Checker to review a specific combination.

Evidence

Evidence Summary

Evidence lens

Read as directional context, not settled clinical proof.

LimitedLimited Evidence

Human clinical evidence: Not the primary signal

Mechanistic / preclinical: Mechanism mapped — Oxidative Stress Modulation

Research maturity: Theoretical / mechanistic research — Mechanistic or unresolved evidence is kept separate from established human outcomes.

Safety boundary: Safety note available — Avoid high dose or chronic supplement use; annonaceous acetogenins have neurotoxicity concerns.

This profile cites 3 human studies.

Study design details
Evidence Grade

Grade C: Limited Evidence

Evaluation of methodological rigor, population reach, and evidence alignment.

Design Match
Narrative review
Risk of Bias
High
Consistency
Not assessed
Strongest recorded design is a narrative review, drawn from 2 recorded studies, none of which measured an outcome in people.
How evidence grades work

Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.

Strong
Multiple RCTs, consistent direction, adequate effect size
Moderate
Some RCTs or consistent observational data in humans
Preliminary / Mixed
Animal or in-vitro only, or conflicting human data
Traditional / Theoretical
Traditional use only; no controlled human trials
Clinical Study Summaries (3)0 human evidence sources · 0 human trials · Participant totals not consistently reported · Consistency not yet classifiable

Filter by study class

Showing 3 of 3 studies.

What the evidence actually shows

This table contains 3 structured sources, including 0 human evidence sources; 0 are human trials.

StudyDesignNDoseDurationPopulationOutcomeResult & magnitudeSource

Pharmacological Activities of Soursop (Annona muricata Lin.)

Mutakin M et al. · Molecules · 2022

Background
Narrative review

Summarizes selected literature without the full prespecified search and selection methods of a systematic review.

——————PubMed →

Soursop (Annona muricata) Properties and Perspectives for Integral Valorization

Santos IL et al. · Foods · 2023

Background
Narrative review

Summarizes selected literature without the full prespecified search and selection methods of a systematic review.

——————PubMed →

Soursop leaf extract and fractions protects against L-NAME-induced hypertension and hyperlipidemia

Nsor OO et al. · Front Nutr · 2024

Background
Other / unclear

The study design is not yet classified clearly enough to infer its place in the evidence hierarchy.

——————PubMed →

Dosing & Timing

No standardized dose
Preparation specific; use standardized product label for Preparation varies by tradition and product form and require source backed dosage review before therapeutic claims.
How Soursop works

Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.

Mechanism Pathway — How Soursop Works

How Soursop WorksSoursop acts on biological target pathways via antioxidant, leading to antioxidant efct.SoursopBiological TargetBiological pathwayAntioxidantAntioxidant EfctCell protection
CompoundTarget / ReceptorMechanismEffect / Outcome
Mechanisms & biological pathways (preclinical)
  • Oxidative Stress Modulation

Compare related active botanicals

Explore botanicals with similar chemistry, effects, or safety considerations in the Botanical Activity Atlas.

Guides that use Soursop

Condition guides

Compare & Sourcing

Compare side-by-side tradeoffs or verify active marker guidelines.

Safety first · Harm reduction

This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.

Learn how we evaluate confidence, safety, and intensity on the methodology page.

Editorial Review

Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.

Editorial Standards →

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