Related Compounds
Compounds connected by the same goals, effects, or research topics.
Herb Profile
Tribulus Terrestris
Tribulus terrestris
Tribulus (Tribulus terrestris) (Tribulus terrestris) carries a Grade B rating — moderate evidence.
Last reviewed: •1 source citedReport a correctionProfile-wide ·B Moderate
Use extra caution — Generally safe; GI upset possible Details
- Evidence
- Moderate Evidence
- Typical onset
- Varies by prep
- Safety rating
- Moderate caution
- Best for
- Sleep
- Avoid / review if
- Hormone Sensitive Conditions (Uncertain), None Well Established
At a glance
From this profile's structured data- Evidence
- Grade B
- Safety
- Generally safe; GI upset possible
- Profile context
- sleep
Next stepsWhere to go next — guides & comparisons
Continue reading
- If you want help sleeping → Sleep guides
- If you want to browse more herbs → All herbs
Safety
Safety & Cautions
Generally safe; GI upset possible
Elevated caution
Caution level: Elevated. One caution category applies — read it before use.
- Hormonal Activity ContextHormone-adjacent wording is present and should be interpreted carefully.
Detailed safety fields
Pregnancy, breastfeeding, and contraindications
- Hormone Sensitive Conditions (Uncertain)
- None Well Established
Safety classifications
- Hormonal Activity Context: Hormone-adjacent wording is present and should be interpreted carefully.
Full safety note
- Generally safe; GI upset possible
Safety labels
- Hormonal Activity Context
Evidence
Evidence Summary
Evidence lens
Useful signal, but study design, dose, and population still matter.
ModerateModerate Evidence
Human clinical evidence: Present in source signals
Mechanistic / preclinical: Mechanism mapped — Vascular Function Support
Research maturity: Established research — Long Term Human Evidence May Be Limited.
Safety boundary: Safety note available — Generally safe; GI upset possible
This profile cites 1 human study.
Study design details
Evidence Grade
Grade B: Moderate Evidence
Evaluation of methodological rigor, population reach, and evidence alignment.
- Design Match
- Randomized controlled trial
- Risk of Bias
- Low
- Consistency
- Mixed
Strongest recorded design is a randomized controlled trial, drawn from 2 recorded studies, 1 in people. Findings across those studies disagree.
How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
- Strong
- Multiple RCTs, consistent direction, adequate effect size
- Moderate
- Some RCTs or consistent observational data in humans
- Preliminary / Mixed
- Animal or in-vitro only, or conflicting human data
- Traditional / Theoretical
- Traditional use only; no controlled human trials
Clinical Study Summaries (1)1 human evidence source · 1 human trial · Participant totals not consistently reported · Consistency not yet classifiable
What the evidence actually shows
This table contains 1 structured source, including 1 human evidence source; 1 is a human trial.
| Study | Design | N | Dose | Duration | Population | Outcome | Result & magnitude | Source |
|---|---|---|---|---|---|---|---|---|
PubMed · J Strength Cond Res · 2007 Background | Randomized controlled trial Randomly assigns participants to interventions or controls, reducing many sources of bias when the trial is conducted well. | — | — | — | — | — | — | PubMed → |
Dosing & Timing
- Dose guidance
- Extracts standardized to saponins: 250 1500 mg/day; variability across products
How Tribulus Terrestris works
Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.
Mechanism Pathway — How Tribulus Terrestris Works
CompoundTarget / ReceptorMechanismEffect / Outcome
Mechanisms & biological pathways (preclinical)
- Vascular Function Support
Active Compounds
Key constituents studied in Tribulus Terrestris, with full pharmacology and safety profiles.
Compare related active botanicals
Explore botanicals with similar chemistry, effects, or safety considerations in the Botanical Activity Atlas.
Guides that use Tribulus Terrestris
Condition guides
Compare & Sourcing
Compare side-by-side tradeoffs or verify active marker guidelines.
Sourcing options
Tribulus Terrestris product picks
Recommendation status
Product recommendations are not shown for this profile because the current site safety and monetization policy does not permit them.
Product form & quality guidelines
When sourcing Tribulus Terrestris, verify the label for:
- Standardized extract: Confirm active content percentages on the supplement facts panel (e.g. standardized to specific marker compounds) rather than simple raw herb weights.
- Third-party testing: Look for independent purity labels (USP, NSF, ConsumerLab, or Eurofins) to ensure the product is free from heavy metals, solvents, and contaminants.
- Form bioavailability: Ensure the form matches evidence-supported configurations (e.g. standardized active extracts like bacosides, withanolides, or curcuminoids) for optimal onset and digestion tolerance.
Continue comparing
Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Editorial Review
Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.
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