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Herb Profile
Stephania Japonica
Stephania japonica
Stephania Japonica (Stephania japonica) carries a Grade C rating — limited evidence.
Last reviewed: •3 sources citedReport a correctionProfile-wide ·C Limited
Use extra caution — Alkaloid rich herb; species substitution and nephrotoxicity/adulteration concerns require caution. Details
- Evidence
- Limited Evidence
- Typical onset
- Varies by prep
- Safety rating
- High caution
- Best for
- Anti Inflammatory, Analgesic, Muscle Relaxant, Stress resilience
- Avoid / review if
- Pregnancy/Breastfeeding Without Clinician Supervision, Known Allergy To The Plant/Family, Potential Interaction Concern With Immunosuppressants
At a glance
From this profile's structured data- Evidence
- Grade C
- Safety
- Alkaloid-rich herb; species substitution and nephrotoxicity/adulteration concerns require caution.
- Profile context
- anti_inflammatory, analgesic, muscle_relaxant
Next stepsWhere to go next — guides & comparisons
Continue reading
- If you want help with anxiety or stress → Anxiety & stress guides
- If you want to browse more herbs → All herbs
Safety
Safety & Cautions
Alkaloid rich herb; species substitution and nephrotoxicity/adulteration concerns require caution. Avoid pregnancy and unsupervised use.
High caution
Caution level: High. Multiple caution categories apply, or the record uses avoid/contraindication language.
- Interaction-AwareMedication or interaction context is explicitly noted.
- Pregnancy/Breastfeeding CautionPregnancy or breastfeeding caution language is present.
Detailed safety fields
Pregnancy, breastfeeding, and contraindications
- Pregnancy/Breastfeeding Without Clinician Supervision
- Known Allergy To The Plant/Family
- Potential Interaction Concern With Immunosuppressants
- Use Clinician Review For High Dose Extracts Or Chronic Use.
Safety classifications
- Interaction-Aware: Medication or interaction context is explicitly noted.
- Pregnancy/Breastfeeding Caution: Pregnancy or breastfeeding caution language is present.
Full safety note
- Alkaloid rich herb; species substitution and nephrotoxicity/adulteration concerns require caution. Avoid pregnancy and unsupervised use.
Safety labels
- Interaction-Aware
- Pregnancy/Breastfeeding Caution
Evidence
Evidence Summary
Evidence lens
Read as directional context, not settled clinical proof.
LimitedLimited Evidence
Human clinical evidence: Not the primary signal
Mechanistic / preclinical: Mechanism mapped — Inflammatory Signaling Modulation · NF KB Modulation
Research maturity: Theoretical / mechanistic research — Mechanistic or unresolved evidence is kept separate from established human outcomes.
Safety boundary: Safety note available — Alkaloid rich herb; species substitution and nephrotoxicity/adulteration concerns require caution.
This profile cites 3 human studies.
Study design details
Evidence Grade
Grade C: Limited Evidence
Evaluation of methodological rigor, population reach, and evidence alignment.
- Design Match
- Narrative review
- Risk of Bias
- High
- Consistency
- Not assessed
Strongest recorded design is a narrative review, drawn from 1 recorded study, none of which measured an outcome in people.
How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
- Strong
- Multiple RCTs, consistent direction, adequate effect size
- Moderate
- Some RCTs or consistent observational data in humans
- Preliminary / Mixed
- Animal or in-vitro only, or conflicting human data
- Traditional / Theoretical
- Traditional use only; no controlled human trials
Clinical Study Summaries (3)0 human evidence sources · 0 human trials · Participant totals not consistently reported · Consistency not yet classifiable
Filter by study class
Showing 3 of 3 studies.
What the evidence actually shows
This table contains 3 structured sources, including 0 human evidence sources; 0 are human trials.
| Study | Design | N | Dose | Duration | Population | Outcome | Result & magnitude | Source |
|---|---|---|---|---|---|---|---|---|
Traditional Herbal Medicines Against CNS Disorders from Bangladesh Uddin MJ et al. · Nat Prod Bioprospect · 2020 Background | Narrative review Summarizes selected literature without the full prespecified search and selection methods of a systematic review. | — | — | — | — | — | — | PubMed → |
Antiviral activity of Stephania japonica extract against porcine epidemic diarrhea virus infection Zhao Y et al. · Vet Microbiol · 2025 Background | Other / unclear The study design is not yet classified clearly enough to infer its place in the evidence hierarchy. | — | — | — | — | — | — | PubMed → |
The genome of Stephania japonica provides insights into the biosynthesis of cepharanthine Liu Z et al. · Cell Rep · 2024 Background | Other / unclear The study design is not yet classified clearly enough to infer its place in the evidence hierarchy. | — | — | — | — | — | — | PubMed → |
Dosing & Timing
- No standardized dose
- Preparation specific; use standardized product label for Preparation varies by tradition and product form and require source backed dosage review before therapeutic claims.
How Stephania Japonica works
Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.
Mechanism Pathway — How Stephania Japonica Works
CompoundTarget / ReceptorMechanismEffect / Outcome
Mechanisms & biological pathways (preclinical)
- Inflammatory Signaling Modulation
- NF KB Modulation
Active Compounds
Key constituents studied in Stephania Japonica, with full pharmacology and safety profiles.
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Guides that use Stephania Japonica
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Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Editorial Review
Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.
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