Herb Profile
Sophora Flavescens
Botanical profile with evidence, safety, and practical fit.
Last reviewed: •3 human studies cited
C PreliminaryUse extra caution — Generally well tolerated for most users. Details
- Evidence
- Limited Human Evidence
- Typical onset
- Varies by prep
- Safety rating
- High caution
- Best for
- Anti Inflammatory, Antiparasitic, Cardiac Support, Inflammatory signaling
- Avoid / review if
- Pregnancy/Breastfeeding, Liver Disease, Arrhythmia/Cardiac Disease Without Clinician Review
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Sophora Flavescens
Generated profile category visual
Where to go next — guides & comparisons
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Safety & Cautions
Generally well tolerated for most users.
28%
High caution — review carefully
Detailed safety fields
Medication interactions
- - Potential Interactions With Hepatotoxic Drugs
- - Antiarrhythmics
- - Immunomodulators
- - And Sedative/CNS Active Medicines Are Plausible And Extract Specific.
Pregnancy, breastfeeding, and contraindications
- - Pregnancy/Breastfeeding
- - Liver Disease
- - Arrhythmia/Cardiac Disease Without Clinician Review
- - Complex Medication Regimens.
Safety classifications
- - Interaction-Aware: Medication or interaction context is explicitly noted.
- - Liver-Sensitive: Liver-related caution language appears in the profile.
- - Pregnancy/Breastfeeding Caution: Pregnancy or breastfeeding caution language is present.
Full safety note
- - Generally well tolerated for most users.
Safety labels
- - Interaction-Aware
- - Liver-Sensitive
- - Pregnancy/Breastfeeding Caution
Evidence-based safety
Caution when combined
These pairings share a flagged risk mechanism. They are additive-effect cautions derived from contraindication data, not confirmed clinical interactions. Consult a clinician before combining.
Moderate Caution
66 flagged pairingsSedation / CNS depression
Moderate Caution
66 flagged pairingsSedation / CNS depression
Browse the grouped cautions below. The list scrolls inside this card when long.
Sedation / CNS depression
- American Yellow Lotus
- Artemisia Absinthium
- Ashwagandha (Withania somnifera)
- Bacopa
- Black Seed
- Black Tea
- Blue Lotus
- Calamus
- Catuba
- Chamomile
- Chinese Skullcap
- Coriandrum Sativum
- Corydalis
- Cymbopogon Citratus
- Damiana
- California Poppy
- Eucalyptus
- Gastrodia
- Gotu Kola (Centella asiatica)
- Hops
- Hypericum Perforatum
- Jatamansi
- Jujube
- L-theanine
- L-Theanine (Sleep Use)
- Lavender
- Lavender
- Lavender Extract
- Lemon balm
- Lemon Balm Extract
- Lemon Verbena
- Lemongrass
- Lobelia Inflata
- Longan
- Magnesium
- Magnolia
- Melatonin
- Lemon Balm
- Milk Oats
- Mugwort
- Muira Puama
- Myristica Fragrans
- Nicotiana Glauca
- Nicotiana Tabacum
- Oatstraw
- Ocimum Basilicum
- Parsley
- Passionflower
- Passionflower
- Passionflower Extract
- Polygala
- Poria
- Raspberry Leaf
- Sage
- Schisandra Berry
- Schisandra Chinensis
- Scutellaria Baicalensis
- Skullcap
- Shankhpushpi
- theanine
- Valeriana officinalis
- Valerian Root Extract
- Valerian
- Verbena Officinalis
- Ashwagandha
- Wormwood
Evidence Summary
Evidence lens
Early signal that needs stronger human replication before practical claims.
PreliminaryLimited Human Evidence
Human clinical evidence: Present in source signals
Mechanistic / preclinical: Mechanism mapped — Inflammatory Signaling Modulation · Immune Signaling Modulation · NF KB Modulation
Research maturity: Preliminary or mixed — Long Term Human Evidence May Be Limited.
Safety boundary: Safety note available — Generally well tolerated for most users.
This profile cites 3 human studies.
How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
A
Strong
Multiple RCTs, consistent direction, adequate effect size
B
Moderate
Some RCTs or consistent observational data in humans
C
Preliminary / Mixed
Animal or in-vitro only, or conflicting human data
D
Traditional / Theoretical
Traditional use only; no controlled human trials
Dosing & Timing
Dose guidance
Preparation specific; use standardized product label for Root is used as decoction and require source backed dosage review before therapeutic claims.
How Sophora Flavescens Works
Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.
Mechanism Pathway — How Sophora Flavescens Works
CompoundTarget / ReceptorMechanismEffect / Outcome
Mechanisms & Biological Pathways
Preclinical pathways
Proposed mechanisms from in vitro and animal research; these do not confirm clinical outcomes in humans.
Inflammatory Signaling ModulationImmune Signaling ModulationNF KB Modulation
Active Compounds
Key constituents studied in Sophora Flavescens, with full pharmacology and safety profiles.
Condition guides
Compare & Sourcing
Compare side-by-side tradeoffs or verify active marker guidelines.
Review available sources for Sophora Flavescens
Independent database mapping — evaluated separately from safety and efficacy scores.
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Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Editorial Review
Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.
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Botanical profile context
How to interpret Sophora Flavescens
Sophora Flavescens dosage ranges, effects, drug interactions, and harm-reduction safety guide for anti inflammatory. Limited Human Evidence research evidence. Use this herb profile as a starting point for evidence review, not as a recommendation to start a new supplement. Botanical products can vary by plant part, extract ratio, standardization, dose, and contaminant testing, so two labels with the same common name may not behave the same way.
When reviewing Sophora Flavescens, compare the traditional-use context against the human evidence, mechanism notes, and safety cautions. Pay special attention to pregnancy, breastfeeding, liver or kidney disease, blood-pressure effects, sedation, stimulation, anticoagulant use, antidepressants, and any prescription medication overlap.
For product decisions, prefer transparent labels, named extracts, clear serving sizes, and third-party quality testing. Avoid treating a long list of possible mechanisms as proof that an herb will solve a specific condition.