Herb Profile
Corydalis
Botanical profile with evidence, safety, and practical fit.
Last reviewed: •3 human studies cited
C PreliminaryUse extra caution — CNS depression, dizziness, sedation, and liver safety concerns have been reported with Corydalis containing products. Details
- Evidence
- Limited Human Evidence
- Typical onset
- Varies by prep
- Safety rating
- High caution
- Best for
- Sleep, Cognitive function
- Avoid / review if
- Pregnancy/Breastfeeding, Liver Disease, Seizure Disorder
Monograph visual
Corydalis
Generated profile category visual
Where to go next — guides & comparisons
Continue reading
- If you want help sleeping → Sleep guides
- If you want to browse more herbs → All herbs
Safety & Cautions
CNS depression, dizziness, sedation, and liver safety concerns have been reported with Corydalis containing products. Avoid combining with sedatives or alcohol.
28%
High caution — review carefully
Detailed safety fields
Pregnancy, breastfeeding, and contraindications
- - Pregnancy/Breastfeeding
- - Liver Disease
- - Seizure Disorder
- - Heavy Alcohol Use
- - And Use Of Sedatives Without Medical Oversight.
- - Potential Additive Effects With Benzodiazepines
- - Opioids
- - Sleep Aids
- - Alcohol
- - Antipsychotics
Safety classifications
- - Liver-Sensitive: Liver-related caution language appears in the profile.
- - Pregnancy/Breastfeeding Caution: Pregnancy or breastfeeding caution language is present.
Full safety note
- - CNS depression, dizziness, sedation, and liver safety concerns have been reported with Corydalis containing products. Avoid combining with sedatives or alcohol.
Safety labels
- - Liver-Sensitive
- - Pregnancy/Breastfeeding Caution
Evidence-based safety
Caution when combined
These pairings share a flagged risk mechanism. They are additive-effect cautions derived from contraindication data, not confirmed clinical interactions. Consult a clinician before combining.
Moderate Caution
68 flagged pairingsSedation / CNS depression
Moderate Caution
68 flagged pairingsSedation / CNS depression
Browse the grouped cautions below. The list scrolls inside this card when long.
Sedation / CNS depression
- American Yellow Lotus
- Artemisia Absinthium
- Ashwagandha (Withania somnifera)
- Bacopa
- Black Seed
- Black Tea
- Blue Lotus
- Calamus
- Catuba
- Celastrus Paniculatus
- Chamomile
- Chinese Skullcap
- Coriandrum Sativum
- Cymbopogon Citratus
- Damiana
- California Poppy
- Eucalyptus
- Gastrodia
- Glycine
- Gotu Kola (Centella asiatica)
- Hops
- Hypericum Perforatum
- Jatamansi
- Jujube
- Lavender
- Lavender
- Lavender Extract
- Lemon balm
- Lemon Balm Extract
- Lemon Verbena
- Lemongrass
- Lobelia Inflata
- Longan
- Magnolia
- Melatonin
- Lemon Balm
- Milk Oats
- Mugwort
- Muira Puama
- Myristica Fragrans
- Nicotiana Glauca
- Nicotiana Tabacum
- Oatstraw
- Ocimum Basilicum
- Parsley
- Passionflower
- Passionflower
- Passionflower Extract
- Passionflower Extract (Standardized)
- Kava
- Polygala
- Poria
- Raspberry Leaf
- Sage
- Schisandra Berry
- Schisandra Chinensis
- Scutellaria Baicalensis
- Skullcap
- Shankhpushpi
- Sophora Flavescens
- theanine
- Valeriana officinalis
- Valerian Extract (Standardized)
- Valerian Root Extract
- Valerian
- Verbena Officinalis
- Ashwagandha
- Wormwood
Evidence Summary
Evidence lens
Early signal that needs stronger human replication before practical claims.
PreliminaryLimited Human Evidence
Human clinical evidence: Present in source signals
Mechanistic / preclinical: Mechanism mapped — Neurotransmitter Modulation
Research maturity: Preliminary or mixed — Long Term Human Evidence May Be Limited.
Safety boundary: Safety note available — CNS depression, dizziness, sedation, and liver safety concerns have been reported with Corydalis containing products.
This profile cites 3 human studies.
How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
A
Strong
Multiple RCTs, consistent direction, adequate effect size
B
Moderate
Some RCTs or consistent observational data in humans
C
Preliminary / Mixed
Animal or in-vitro only, or conflicting human data
D
Traditional / Theoretical
Traditional use only; no controlled human trials
Clinical Study Summaries (3)Cited studies informing this profile. RCTs and reviews shown first.
| Study | Type | Sample | Source |
|---|---|---|---|
The Analgesic Properties of Corydalis yanhusuo Alhassen L et al. (2021) | — | — | PubMed → |
Wu L et al. (2021) | — | — | PubMed → |
Jin C et al. (2024) | — | — | PubMed → |
Dosing & Timing
Dose guidance
Preparation specific; use standardized product label for Evidence and risks depend strongly on species and require source backed dosage review before therapeutic claims.
How Corydalis Works
Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.
Mechanism Pathway — How Corydalis Works
CompoundTarget / ReceptorMechanismEffect / Outcome
Mechanisms & Biological Pathways
Preclinical pathways
Proposed mechanisms from in vitro and animal research; these do not confirm clinical outcomes in humans.
Neurotransmitter Modulation
Condition guides
Compare & Sourcing
Compare side-by-side tradeoffs or verify active marker guidelines.
Review available sources for Corydalis
Independent database mapping — evaluated separately from safety and efficacy scores.
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Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Editorial Review
Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.
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Botanical profile context
How to interpret Corydalis
Corydalis dosage ranges, effects, drug interactions, and harm-reduction safety guide for sleep. Limited Human Evidence research evidence. Use this herb profile as a starting point for evidence review, not as a recommendation to start a new supplement. Botanical products can vary by plant part, extract ratio, standardization, dose, and contaminant testing, so two labels with the same common name may not behave the same way.
When reviewing Corydalis, compare the traditional-use context against the human evidence, mechanism notes, and safety cautions. Pay special attention to pregnancy, breastfeeding, liver or kidney disease, blood-pressure effects, sedation, stimulation, anticoagulant use, antidepressants, and any prescription medication overlap.
For product decisions, prefer transparent labels, named extracts, clear serving sizes, and third-party quality testing. Avoid treating a long list of possible mechanisms as proof that an herb will solve a specific condition.