Herb Profile
Glycyrrhiza Glabra
Botanical profile with evidence, safety, and practical fit.
Last reviewed: •3 human studies cited
C PreliminaryUse extra caution — Generally well tolerated for most users. Details
- Evidence
- Limited Human Evidence
- Typical onset
- Varies by prep
- Safety rating
- Moderate caution
- Best for
- Anti Inflammatory, Inflammatory signaling
- Avoid / review if
- Hypertension, Kidney Disease, Hypokalemia
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Glycyrrhiza Glabra
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Safety & Cautions
Generally well tolerated for most users.
60%
Moderate caution — review before use
Detailed safety fields
Medication interactions
- - High Risk With Diuretics
- - Corticosteroids
- - Digoxin
- - Antihypertensives
- - Antiarrhythmics
- - And Stimulant Laxatives.
Pregnancy, breastfeeding, and contraindications
- - Hypertension
- - Kidney Disease
- - Hypokalemia
- - Heart Disease
- - Pregnancy
- - Use With Diuretics/Corticosteroids/Digoxin Without Review
Safety classifications
- - Stimulant-Like Profile: Stimulant-like or activating caution language is present.
Full safety note
- - Generally well tolerated for most users.
Safety labels
- - Stimulant-Like Profile
Evidence-based safety
Caution when combined
These pairings share a flagged risk mechanism. They are additive-effect cautions derived from contraindication data, not confirmed clinical interactions. Consult a clinician before combining.
Moderate Caution
56 flagged pairingsBlood-pressure effects
Moderate Caution
56 flagged pairingsBlood-pressure effects
Browse the grouped cautions below. The list scrolls inside this card when long.
Blood-pressure effects
- ajoene
- Allicin
- Andrographis
- Angelica Dahurica
- Astragalus Membranaceus
- Berberis
- Bicarbonate
- Black Seed
- Brassica Oleracea
- Buckwheat
- Capsicum
- Chuanxiong
- Citicoline
- Citrus Bergamia
- Cnidium Monnieri
- Coenzyme Q10
- Coffee Cherry
- Coleus Forskohlii
- Coenzyme Q10
- Cymbopogon Citratus
- Dandelion
- Danshen
- Devils Claw Extract
- Electrolyte Mix
- Eleuthero
- Epimedium
- Epimedium Brevicornum
- Eucommia
- ferulic acid
- Gastrodia
- Guarana
- Guayusa
- Hibiscus
- Huperzia Serrata
- L-theanine
- Lemongrass
- Licorice
- Ligusticum Chuanxiong
- Lobelia Inflata
- Luo Han Guo
- Moringa
- Mucuna
- Myristica Fragrans
- Nicotiana Glauca
- Nicotiana Tabacum
- Nigella Sativa
- Notoginseng
- Olive Leaf
- Parsley
- Poria
- PT-141 (Bremelanotide)
- Punarnava
- Sodium
- Ashwagandha
- Yerba Mate
- Yohimbe
Evidence Summary
Evidence lens
Early signal that needs stronger human replication before practical claims.
PreliminaryLimited Human Evidence
Human clinical evidence: Present in source signals
Mechanistic / preclinical: Mechanism mapped — Inflammatory Signaling Modulation
Research maturity: Preliminary or mixed — Long Term Human Evidence May Be Limited.
Safety boundary: Safety note available — Generally well tolerated for most users.
This profile cites 3 human studies.
How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
A
Strong
Multiple RCTs, consistent direction, adequate effect size
B
Moderate
Some RCTs or consistent observational data in humans
C
Preliminary / Mixed
Animal or in-vitro only, or conflicting human data
D
Traditional / Theoretical
Traditional use only; no controlled human trials
Clinical Study Summaries (3)Cited studies informing this profile. RCTs and reviews shown first.
| Study | Type | Sample | Source |
|---|---|---|---|
Toxicological Effects of Glycyrrhiza glabra (Licorice): A Review Nazari S et al. (2017) | — | — | PubMed → |
Liquorice (Glycyrrhiza glabra): A phytochemical and pharmacological review Pastorino G et al. (2018) | — | — | PubMed → |
Fugh-Berman A et al. (2000) | — | — | PubMed → |
Dosing & Timing
Dose guidance
Preparation specific; use standardized product label for Whole root and require source backed dosage review before therapeutic claims.
How Glycyrrhiza Glabra Works
Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.
Mechanism Pathway — How Glycyrrhiza Glabra Works
CompoundTarget / ReceptorMechanismEffect / Outcome
Mechanisms & Biological Pathways
Preclinical pathways
Proposed mechanisms from in vitro and animal research; these do not confirm clinical outcomes in humans.
Inflammatory Signaling Modulation
Active Compounds
Key constituents studied in Glycyrrhiza Glabra, with full pharmacology and safety profiles.
Condition guides
Compare & Sourcing
Compare side-by-side tradeoffs or verify active marker guidelines.
Review available sources for Glycyrrhiza Glabra
Independent database mapping — evaluated separately from safety and efficacy scores.
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Affiliate-ready sourcing
Licorice Root product picks
Affiliate recommendations for Glycyrrhiza Glabra. Review safety, dose, and product quality before buying.
Affiliate disclosure: we may earn a commission from qualifying links at no extra cost to you.
Product Form & Quality Guidelines
When sourcing Glycyrrhiza Glabra, verify the label for:
- Standardized Extract: Confirm active content percentages on the supplement facts panel (e.g. standardized to specific marker compounds) rather than simple raw herb weights.
- Third-Party Testing: Look for independent purity labels (USP, NSF, ConsumerLab, or Eurofins) to ensure the product is free from heavy metals, solvents, and contaminants.
- Form Bioavailability: Ensure the form matches evidence-supported configurations (e.g. standardized active extracts like bacosides, withanolides, or curcuminoids) for optimal onset and digestion tolerance.
Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Editorial Review
Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.
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Botanical profile context
How to interpret Glycyrrhiza Glabra
Glycyrrhiza Glabra dosage ranges, effects, drug interactions, and harm-reduction safety guide for anti inflammatory. Limited Human Evidence research evidence. Use this herb profile as a starting point for evidence review, not as a recommendation to start a new supplement. Botanical products can vary by plant part, extract ratio, standardization, dose, and contaminant testing, so two labels with the same common name may not behave the same way.
When reviewing Glycyrrhiza Glabra, compare the traditional-use context against the human evidence, mechanism notes, and safety cautions. Pay special attention to pregnancy, breastfeeding, liver or kidney disease, blood-pressure effects, sedation, stimulation, anticoagulant use, antidepressants, and any prescription medication overlap.
For product decisions, prefer transparent labels, named extracts, clear serving sizes, and third-party quality testing. Avoid treating a long list of possible mechanisms as proof that an herb will solve a specific condition.