Herb Profile
Paeonia Lactiflora
Botanical profile with evidence, safety, and practical fit.
Last reviewed: •3 human studies cited
C PreliminaryUse extra caution — May affect coagulation or immune signaling; use caution around anticoagulation. Details
- Evidence
- Limited Human Evidence
- Typical onset
- Varies by prep
- Safety rating
- Moderate caution
- Best for
- Anti Inflammatory, Hormonal, Analgesic, Inflammatory signaling
- Avoid / review if
- Pregnancy Without Clinician Guidance, Anticoagulant Use Without Review, Potential Additive Bleeding Risk With Anticoagulants/Antiplatelets
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Paeonia Lactiflora
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Safety & Cautions
May affect coagulation or immune signaling; use caution around anticoagulation.
60%
Moderate caution — review before use
Detailed safety fields
Pregnancy, breastfeeding, and contraindications
- - Pregnancy Without Clinician Guidance
- - Anticoagulant Use Without Review
- - Potential Additive Bleeding Risk With Anticoagulants/Antiplatelets
- - May Interact With Immunomodulators.
Safety classifications
- - Anticoagulant Caution: Bleeding or anticoagulant-adjacent caution language is present.
Full safety note
- - May affect coagulation or immune signaling; use caution around anticoagulation.
Safety labels
- - Anticoagulant Caution
Evidence-based safety
Caution when combined
These pairings share a flagged risk mechanism. They are additive-effect cautions derived from contraindication data, not confirmed clinical interactions. Consult a clinician before combining.
High-Priority Caution
147 flagged pairingsBleeding / anticoagulant risk
High-Priority Caution
147 flagged pairingsBleeding / anticoagulant risk
Browse the grouped cautions below. The list scrolls inside this card when long.
Bleeding / anticoagulant risk
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- Angelica Dahurica
- Angelica Pubescens
- Angelica Root
- Angelica Sinensis
- Arjuna
- Artemisia Capillaris
- Artichoke
- Ashitaba
- Ashitaba Extract
- Astaxanthin
- Berberis
- Black Seed
- Black Seed Oil
- Blueberry
- Boldo
- Boswellia
- Capsicum
- Caraway
- Carnitine L Tartrate
- Cayenne
- Chamomile
- Chinese Skullcap
- Chuanxiong
- Cissus
- Citicoline
- Clove
- Cnidium Monnieri
- Coleus Forskohlii
- Commiphora Mukul
- Coenzyme Q10
- Cordyceps
- Cranberry (Vaccinium macrocarpon)
- crocetin
- crocin
- cryptotanshinone
- Curcuma Wenyujin
- Curcumin
- Damiana
- Danshen
- Devils Claw Extract
- Dong Quai
- EGCG
- Epimedium
- Epimedium Brevicornum
- Evening Primrose (Oenothera biennis)
- Fenugreek
- Fenugreek Extract
- ferulic acid
- Feverfew
- Fisetin
- forskolin
- Fraxinus Rhynchophylla
- Fucoxanthin
- Galangal
- Reishi
- Garcinia Mangostana
- Garlic (Allium sativum)
- Garlic Aged Extract
- Garlic Extract
- Ginger (Zingiber officinale)
- Ginkgo
- Ginkgo Biloba Extract
- Ginkgo Extract EGb 761
- Panax Red Ginseng
- Panax White Ginseng
- ginsenoside rg3
- Glucosamine
- Goldenseal
- Lion's Mane
- Holy Basil / Tulsi (Ocimum tenuiflorum)
- Horse Chestnut
- hydroxytyrosol
- Japanese Knotweed
- Kudzu
- L-Carnitine
- Ligusticum Chuanxiong
- Magnolia
- Mangosteen
- Maral Root
- Chamomile
- Melatonin
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- Nettle Root
- Nigella Sativa
- Noni
- Notoginseng
- Ocimum Basilicum
- Olive Leaf Extract
- Oregano
- Asian Ginseng
- Panax Ginseng Extract
- Papaya Leaf
- Pastinaca Sativa
- Pau D'arco
- Perilla
- Phosphatidylserine
- Piper Longum
- Bifidobacterium Probiotic
- Lactobacillus Probiotic
- Probiotics - Bifidobacterium spp.
- Probiotics - Lactobacillus spp.
- Psoralea Corylifolia
- Pycnogenol
- Quercetin
- Quercetin Phytosome
- Red Clover
- Reishi (Ganoderma lucidum)
- Resveratrol
- Rhodiola Extract SHR-5
- Rose Hips
- Rosemary
- Saffron
- Saffron Extract
- Salvia miltiorrhiza
- Saw Palmetto (Serenoa repens)
- Saw Palmetto Extract
- Schisandra Berry
- Schisandra Chinensis
- Scutellaria Baicalensis
- Selaginella Tamariscina
- Soybean
- Syzygium Aromaticum
- Terminalia arjuna
- Thunder God Vine
- Thyme
- Tongkat Ali
- Trans-Resveratrol
- Fenugreek
- Tripterygium Wilfordii
- Turmeric (Curcuma longa)
- Turmeric Curcumin + Piperine
- Valerian
- Vitamin D3 + K2
- Grape
- White Peony
- Willow Bark Extract
- Yarrow
Evidence Summary
Evidence lens
Early signal that needs stronger human replication before practical claims.
PreliminaryLimited Human Evidence
Human clinical evidence: Present in source signals
Mechanistic / preclinical: Mechanism mapped — Inflammatory Signaling Modulation · Immune Signaling Modulation · Hormonal Signaling Context
Research maturity: Preliminary or mixed — Long Term Human Evidence May Be Limited.
Safety boundary: Safety note available — May affect coagulation or immune signaling; use caution around anticoagulation.
This profile cites 3 human studies.
How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
A
Strong
Multiple RCTs, consistent direction, adequate effect size
B
Moderate
Some RCTs or consistent observational data in humans
C
Preliminary / Mixed
Animal or in-vitro only, or conflicting human data
D
Traditional / Theoretical
Traditional use only; no controlled human trials
Clinical Study Summaries (3)Cited studies informing this profile. RCTs and reviews shown first.
| Study | Type | Sample | Source |
|---|---|---|---|
Weng J et al. (2023) | — | — | PubMed → |
Anti-inflammatory and immunoregulatory effects of paeoniflorin and total glucosides of paeony Zhang L et al. (2020) | — | — | PubMed → |
PubMed indexed authors (2006) | — | — | PubMed → |
Dosing & Timing
Dose guidance
Preparation specific; use standardized product label for Root decoction/extract and require source backed dosage review before therapeutic claims.
How Paeonia Lactiflora Works
Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.
Mechanism Pathway — How Paeonia Lactiflora Works
CompoundTarget / ReceptorMechanismEffect / Outcome
Mechanisms & Biological Pathways
Preclinical pathways
Proposed mechanisms from in vitro and animal research; these do not confirm clinical outcomes in humans.
Inflammatory Signaling ModulationImmune Signaling ModulationHormonal Signaling ContextNF KB Modulation
Active Compounds
Key constituents studied in Paeonia Lactiflora, with full pharmacology and safety profiles.
Condition guides
Compare & Sourcing
Compare side-by-side tradeoffs or verify active marker guidelines.
Review available sources for Paeonia Lactiflora
Independent database mapping — evaluated separately from safety and efficacy scores.
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Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Editorial Review
Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.
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Botanical profile context
How to interpret Paeonia Lactiflora
Paeonia Lactiflora dosage ranges, effects, drug interactions, and harm-reduction safety guide for anti inflammatory. Limited Human Evidence research evidence. Use this herb profile as a starting point for evidence review, not as a recommendation to start a new supplement. Botanical products can vary by plant part, extract ratio, standardization, dose, and contaminant testing, so two labels with the same common name may not behave the same way.
When reviewing Paeonia Lactiflora, compare the traditional-use context against the human evidence, mechanism notes, and safety cautions. Pay special attention to pregnancy, breastfeeding, liver or kidney disease, blood-pressure effects, sedation, stimulation, anticoagulant use, antidepressants, and any prescription medication overlap.
For product decisions, prefer transparent labels, named extracts, clear serving sizes, and third-party quality testing. Avoid treating a long list of possible mechanisms as proof that an herb will solve a specific condition.